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Multiple Choice

Which medication is indicated to control muscle cramps from a black widow bite?

Muscle cramps from a black widow bite come from the venom’s intense stimulation of nerve signals to muscles, causing sustained contractions. To counter these cramps, you want a medication that quiets CNS activity and relaxes skeletal muscle. Benzodiazepines do this by enhancing GABA’s inhibitory effect in the brain, which reduces neuronal excitability and relieves muscle spasm. They’re effective for the severe, painful cramps seen with black widow envenomation and can also provide calming effects that help with distress and anxiety. Morphine focuses on pain relief but doesn’t address the underlying muscle spasms and can alter perception of symptoms and respiration. Diphenhydramine is an antihistamine with sedative properties but isn’t reliable for stopping or reducing cramping. Acetaminophen can treat pain but not the muscle contractions. So the medication best suited to control the cramps is a benzodiazepine.

Muscle cramps from a black widow bite come from the venom’s intense stimulation of nerve signals to muscles, causing sustained contractions. To counter these cramps, you want a medication that quiets CNS activity and relaxes skeletal muscle. Benzodiazepines do this by enhancing GABA’s inhibitory effect in the brain, which reduces neuronal excitability and relieves muscle spasm. They’re effective for the severe, painful cramps seen with black widow envenomation and can also provide calming effects that help with distress and anxiety.

Morphine focuses on pain relief but doesn’t address the underlying muscle spasms and can alter perception of symptoms and respiration. Diphenhydramine is an antihistamine with sedative properties but isn’t reliable for stopping or reducing cramping. Acetaminophen can treat pain but not the muscle contractions. So the medication best suited to control the cramps is a benzodiazepine.