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Multiple Choice

Procainamide maintenance infusion rate is:

The key idea is maintaining a stable therapeutic level of procainamide after the loading dose. For a maintenance IV infusion, the standard range is 1-4 mg per minute. This rate helps keep the drug’s plasma concentration in the therapeutic window (roughly around 4-10 mcg/mL for the parent drug, with consideration of its active metabolite). Infusing too slowly won’t sustain effective antiarrhythmic control, while infusing too quickly raises the risk of toxicity, including hypotension, QRS widening, and other adverse effects. So 1-4 mg/min is the appropriate maintenance range.

The key idea is maintaining a stable therapeutic level of procainamide after the loading dose. For a maintenance IV infusion, the standard range is 1-4 mg per minute. This rate helps keep the drug’s plasma concentration in the therapeutic window (roughly around 4-10 mcg/mL for the parent drug, with consideration of its active metabolite). Infusing too slowly won’t sustain effective antiarrhythmic control, while infusing too quickly raises the risk of toxicity, including hypotension, QRS widening, and other adverse effects. So 1-4 mg/min is the appropriate maintenance range.